![]() ![]() This stimulated the creation of several data repositories attempting to store and integrate biological information and to make it available to researchers. ![]() In the past decade, high-throughput technologies produced a huge amount of biological data. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. CUP B15G13000010006 awarded by the Regione Valle dAosta for the project: “Open Health Care Network Analysis” and by the Italian Ministry of Education, University & Research (MIUR) (Project PRIN 2010, MIND). įunding: This work has been partially supported by Grant No. ReNE can be freely installed from the Cytoscape App Store ( ) and the full source code is freely available for download through a SVN repository accessible at. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The authors confirm that all data underlying the findings are fully available without restriction. Received: JAccepted: DecemPublished: December 26, 2014Ĭopyright: © 2014 Politano et al. PLoS ONE 9(12):Įditor: Julio Vera, University of Erlangen-Nuremberg, Germany The reliability of the introduced interactions only depends on the reliability of the source data, which is out of control of ReNe developers.Ĭitation: Politano G, Benso A, Savino A, Di Carlo S (2014) ReNE: A Cytoscape Plugin for Regulatory Network Enhancement. ReNE enhances a network by only integrating data from public repositories, without any inference or prediction. The enhanced network produced by ReNE is exportable in multiple formats for further analysis via third party applications. The resulting enhanced network is still a fully functional Cytoscape network where each regulatory element (transcription factor, miRNA, gene, protein) and regulatory mechanism (up-regulation/down-regulation) is clearly visually identifiable, thus enabling a better visual understanding of its role and the effect in the network behavior. The normalized network is then analyzed to include missing transcription factors, miRNAs, and proteins. The merged network structure is normalized to guarantee a consistent and uniform description of the network nodes and edges and to enrich all integrated data with additional annotations retrieved from genome-wide databases like NCBI, thus producing a pathway fully manageable through the Cytoscape environment. Moreover, ReNE allows researchers to merge multiple pathways coming from different sources. ReNE can automatically import a network layout from the Reactome or KEGG repositories, or work with custom pathways described using a standard OWL/XML data format that the Cytoscape import procedure accepts. In this context, we introduce ReNE, a Cytoscape 3.x plugin designed to automatically enrich a standard gene-based regulatory network with more detailed transcriptional, post transcriptional, and translational data, resulting in an enhanced network that more precisely models the actual biological regulatory mechanisms. To integrate networks with post transcriptional regulatory data, researchers are therefore forced to manually resort to specific third party databases. Regulatory networks are commonly limited to gene entities. Despite post transcriptional regulatory elements (i.e., miRNAs) are widely investigated in current research, their usage and visualization in biological networks is very limited. One of the biggest challenges in the study of biological regulatory mechanisms is the integration, americanmodeling, and analysis of the complex interactions which take place in biological networks.
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![]() Yet, canaries have become ubiquitous with mining in general and as a figure of speech.Īnd we are your historians for this episode of Dig.Įlizabeth: So we’re doing this animal series at the behest of Marissa. In the grand scheme of things, that’s not a long time at all. They were only used as sentinel animals in British and American coal mines for roughly 100 years. Marissa: Contrary to popular belief, canaries in coal mines do not have a very long history. In the case of coal mining, canaries - or really any small bird - are very susceptible to changes in air quality because of their rate of respiration, anatomy, and small size. Often animals are used as sentinels because they are more susceptible to environmental hazards that humans may be in the same environment. The canary in the coal mine is now a metaphor for something horrible about to happen whether it be a financial crisis, a world health issue, or the whims of fashion.Įlizabeth: Metaphors aside, canaries are a sentinel species, used by humans to detect environmental risks by providing advance warning of a danger. The practice was so commonplace that it’s become a cliche. ![]() Like our fictional vignette of a miner carrying a canary into the coal mine, canaries were often taken into mines during the first part of the 20th century to test the air for poisonous gasses. Marissa: The term “canary in a coal mine” is ubiquitous for any early warning signal. Humming with Seymour as he chortles in the small cage you carry him in, you walk towards the end of this tunnel to begin your shift. Picking up Seymour you step out onto the slick ground. ![]() You Seymour’s little cage down for a minute and heave the squeaking metal gate aside. That bird will save your life, and the lives of hundreds of others down in these mines.įinally the creaking cage comes to a stop at the bottom of the shaft. But little chirping Seymour is not insignificant. Contemplating such a serious name for such a small, insignificant animal you hum a tune as the steel wire rope lowers your cage further down and down into the depths. Looking down at the small box you are carrying you smile at your little buddy, a small yellow bird named Seymour. This thing will keep you breathing if things go south down there, or if tweety here starts acting kooky. The tubes run along each side of your head, draping over each shoulder and connecting to a big, hard, yellow backpack attached to your shoulders with more straps. There are leather straps with two buckles holding two metal and canvas tubes against your mouth. You chuckle as you think what Millie, your wife, would say if she saw you in this get up. This is just a routine trip for you, checking the air quality before your crewmates head down. You do this descent daily and the innate panic your body’s defense mechanisms should kick on as you plunge into the depths is only a whisper now. Even with this silly breathing tube contraption you’ve got on your face, you can still smell the mine. The dank air feels cool and smells like dirt and wetness. The air gets colder and colder as the light disappears from above and you are plunged into darkness, lit only by a single dim bulb attached to your helmet. Elizabeth: It’s 1926 and you’re in a mine cage, a type of elevator contraption that slowly descends down the shaft of a coal mine. ![]() The players' decision to skip the game over the jersey has sparked an outpouring of public outrage, including from their own fans and club legends, while others have supported their freedom of religious beliefs. The Sea Eagles unveiled the pride jersey - called Everyone in League - on Monday to promote inclusivity of LGBT + people in the NRL.īut star players Josh Aloiai, Jason Saab, Christian Tuipulotu, Josh Schuster, Haumole Olakau'atu, Tolutau Koula and Toafofoa Sipley refused to wear it on Thursday, saying it would be against their religious beliefs.ĪRLC chairman Peter V'landys (pictured) later downplayed the latest off-field saga to rock the NRL and insists it's not a political issue Now, the Penn family - who have pumped an estimated $20 million into Manly over the years - are back in the limelight amid the row over the jersey. The older Mr Penn is also thought to be a key figure in anti-obesity lobbying in Australia. ![]() Rick and his wife Heather helped launch aerobics in Australia in the late 1970s before moving onto Weight Watchers in the mid-1980s. Rick is the former CEO of Weight Watchers Australia and New Zealand and is one of the richest businessmen in the country. Though Mr Penn has been the main driver of his family's interests in Manly, his father Rick is the head of the family. The app program is already the third largest in the Australian online weight loss market and the Sea Eagles wants to spread its popularity through North America. In April, Mr Penn announced that his firm's Mayo Clinic Diet app was being launched globally and targeting $100m in revenue by 2025. ![]() 'With Super League, pokie tax, and leagues clubs not being able to fund clubs as much as they used to, it had to happen.' 'I spent about eight weeks a year in the US for a six-year period, and I saw private ownership of teams over there, and always on the plane trip coming back, I'd think, 'Why aren't any of the NRL teams privatised?',' Penn said at the time. Speaking about how he led the privatisation of the Sea Eagles in 2004, Mr Penn previously said his experience in the US drove him. So fundamentally it's all about numbers and trends and giving people what they want.' And same with the team performance on the field, if they're not playing well the crowd won't come back. 'We've got to make sure that every interaction we have with a member or patient is as good as it can possibly be or they won't come back. 'With the football team you have elite athletes who have to perform every single week in order to achieve the ultimate premiership, which is to win a championship, and we've got that same mindset with the health business. ![]() 'A lot of people said why am I running both a health business and a football team, but the reality is that they're both all about playing at an elite level,' Mr Penn told the Australian. In another interview, he said: 'I personally was an overweight teenager and I've spent my last 25 years in this space, it really is my passion.'ĭigital Wellness has an approximate valuation of between $US120m to $US150m. To avoid this, we need to shift the way society as a whole thinks about weight and wellness. 'Living longer, but in misery, doesn't sound pleasant. Mr Penn is a Harvard graduate who also attended Knox Grammar and is also the CEO of Digital Wellness, a company that claims to 'power the world's most renowned and trusted weight loss programs' ![]() Manually repositioned several convos for this and stylistic purposes.
![]() We believe that hybrid work is already reshaping customer service, while changing how businesses operate and work with their customers.Īnother trend that will dominate call centers shortly is the number of enterprise businesses switching over to cloud call centers. According to a recent McKinsey study, nine out of ten organizations will be combining remote and on-site working. The second trend with a strong impact in our sector this year is hybrid and remote work. AI and ML have become a large part of customer service over the past year and continue to take the call center industry by storm. The first trend is the use of AI and machine learning. ![]() There are a few trends that are shaping the future of the call center. Read More: SalesTechStar Interview with Dana Bjornson, Chief Financial Officer, Mylo Can you share five major trends that you feel will dominate contact centers in the near future? Hence our roadmap and future investments. The impact of AI is yet to become significant, especially in its widespread use, whereby it becomes pervasive in customer interactions and helps enrich or automate what can be, and focus conversations on the most interactive human to human moments. Can you talk about the impact of AI on contact centers and how AI powered technologies will create a new mode of work? Olivier Pailhes, CEO at Aircall We believe the future of the market will be in developing application ecosystems with integrations that allow for any possible use case and fully customized usage within existing processes & workflows. ![]() We recognized this early on and built Aircall as an API first product that existing tools can be built on top of. Productivity in communication is a cornerstone of competition for companies and brands, so any technology that prioritizes this, will be game changing for the market. CCaaS and UCaaS are emerging as the two core models, which opens the door for growth among cloud-based contact center solutions like Aircall. Over the past few years, changing consumer behavior and digital transformation have been driving innovation for contact center technology. Read More: Raydiant Partners with Retail Analytics Platform RetailNext to Automate Occupancy Tracking for Retailers How are you seeing the contact center industry shift today and what are some key features and technologies that you feel are changing the game for this market? We are hoping that our work in improving our technology will positively impact the call center industry as a whole and show that investing in customer experience and partnerships help produce both productivity, and better moments through richer conversations. With the funding from this recent announcement, we’ll be investing in improving our technology with new AI capabilities and additional productivity features for call centers, including machine learning, sentiment analysis, and insights. These three themes will be implicated in Aircall’s product roadmap to deliver rich and insightful moments between our customers and theirs. These focus areas are call analytics, conversational context, and speech recognition. We believe that three key focus areas drive customer interest, and loyalty. We are dedicated to ensuring that our investments in our technology will continue to empower professionals to have richer business conversations. We always had the powerful drive to help millions of professionals create better communication between them and their customers. Aircall’s cloud based phone solution modernizes the customer experience and enables support and sales agents to have smarter conversations. Over the past year, companies of all sizes experienced an accelerated growth in their digital transformation, and at the same time, their customers increased their expectations around personalized and convenient service. With this fundraise, we can continue our mission of changing how professionals use the phone on a daily basis. Thank you, we are excited to share the news and are thrilled with Aircall’s quick growth. _ Hi Olivier, congratulations on the recent funding and valuation! What are your comments on the impact of this to the contact center industry and the future of Aircall? Leading cloud-based voice platform provider Aircall recently announced a $120M Series D funding round led by Goldman Sachs CEO at Aircall – Olivier Pailhes has a chat with SalesTechStar to discuss the funding further as well as what it means for the company and contact center industry: ![]() Invaded the star system in hollowed out planetoids called Labyrinth Ships. So I asked Robert to give me five things that should make me get excitedīeing one for following directions, Robert gave me six:Ĭan pilot with your entire party as bridge crew and gunners. ![]() Starfinder, except you already know you like it!Īnother rulebook makes me shudder with horror. Support rules for every published class, and fully supports all Pathfinder Of your Pathfinder products with it! Aethera is a massive 500+ page tome thatĬovers an entire star system, with new races, new classes, new archetypes and Starfinder, but with a more low-tech, analog and magic hybrid technology I asked Robert Brookes, publisher of the Aethera Campaign Setting, to tell meĭieselpunk setting for Pathfinder! Imagine And in the meantime, there’sĪlready another Pathfinder-but-in-space book you can get your hands on right You know you’re going to be able to get Starfinder in a fewĭays at your local gaming store. Some of you reading this right now-who are pretty bummed at this moment. Which means that there are likely a lot of fans-possibly
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Interestingly, you can also add music and embed videos to your sliders. It is an online solution with unlimited storage and compatibility with many platforms like Joomla and WordPress. CincopaĬincopa is a cloud-like solution to create slideshows using its simple slideshow maker wizard. Moreover, its slideshow features include full-width support, autoplay option, navigation and thumbnail support, etc. You can choose from ready-made color schemes to create lightweight image sliders. It offers a lot of animation effects and image editing features. cssSliderĬssSlider is a pure-CSS, i.e., no-jQuery, no-JavaScript slider solution. ![]() and avails a lot more features in its pro version such as social sharing options, shopping cart support, music support, advanced theming, etc. It comes with vector icons, Flickr support, etc. ![]() If you do not require HTML, you can install and use one of its plugins for WordPress, Lightroom, Photoshop, and more. Juicebox is a spectacular image gallery creator which lets you create web galleries without coding. However, it does not support many publishing platforms or content services like Flickr and YouTube, like few above solutions. What I liked is it provides lots of demos and examples, which will help anyone to get up and running quickly with this slider solution. It also avails both jQuery and no-jQuery sliders and a plugin for WordPress. Jssor Slider is a compelling content and image slider with 300+ transition effects. Lastly, you can add multi-media from several sources, including YouTube. Amazingly, it assists you in publishing your sliders and generates HTML or modules for WordPress, Drupal, and Joomla. It provides beautiful themes, transition effects, and support for designing custom templates. ![]() Hi Slider helps create image sliders with zero coding. It also offers lots of pre-designed themes, import and export features, and includes a no-jQuery, CSS-only fallback as well. You can quickly embed it anywhere, thanks to its ‘Insert-to-Page Wizard’ and save-as-plugin options for Joomla and WordPress. WOW Slider is a jQuery-based image slider that comes with amazing visual effects and helps you create sliders with a few clicks. Image galleries and sliders are among the most popular use cases of jQuery. Free jQuery Image Galleries & Sliders – Best Of ![]() UltraEdit is used by programmers to code and edit all kinds of programming languages including C/C++, Java, Perl, Python, PHP, JavaScript, HTML, CSS and more. UltraEdit for Linux UltraEdit text editor for Linux feature list UltraEdit for Linux is a powerful text editor with a vast array of features. Offset of character from start of file in decimal/hex.Value of character in decimal/hex and display.Character properties pop-up dialog to show:.Auto-correction of syntax-highlighted keywords. ![]() Selected number to binary, octal, decimal or hexadecimal.Standard on all 32-bit Windows platforms.Multi-byte support with integrated IME support.The find symbol command will locate any symbol in the ctag file of the selected item or the item under cursor and position it in appropriate file… That’s the power of UltraEdit! UltraEdit text editor also includes powerful CTAGS support.īuild a project-specific ctag file with the option to create automatically when opened, with fully configurable parameters and tag file for use outside of projects. Natively supports C/C++, Cobol, Fortran, Pascal, Perl, Plb, Visual Basic, Vb Script, ASP, C#, CSS, TeX / LaTeX, HTML, Java, Javascript, Ecma / Ecmascript, PHP, Python, XML, Microsoft Assembler, AT&T Assembler, and Netwide Assembler. UltraEdit includes brace matching, code folding and more. Wordfiles available for hundreds of languageĪ hallmark of UltraEdit text editor is its language-specific support.Support for up to 20 languages in one wordfile.Nearly 500 wordfiles for different languages available.HTML, Java, Perl, XML, PHP, JavaScript, and CSS.Pre-configured for C/C++, Visual Basic, C#, VBScript, ASP.C/C++, HTML, XML, Java, Perl, PHP and more.Toggle between binary (hex mode) and ASCII view.Automatic save back to server without logon requirement.Configuration options for temp files and large file handling.Minimum RAM used even for multi-megabyte files.In addition to the standard editing functions such as undo, copy and paste, and searching, UltraEdit’s color-coded editor allows programmers to decipher different code types and variables, and you are going to love the powerful code-folding too.Īdditional productivity enhancing features include delimiter matching that shows you the location of the opening and closing of parentheses, and bookmarking which helps you remember and find significant sections of code such as subroutines and constant declarations. UltraEdit delivers easy viewing and editing of code and variables. This appears to be a problem with its UDF output format.UltraEdit Editor for Programming & Development Color coded editor, syntax highlighting, and bookmarks Now also available for Linux Several users have reported problems with XML Notepad 2007 writing files that can no The following tools have been reported to not work well with JMRI. Free Editors Crimson Editor CotEditor (OS X)Įditra Edxor jEdit Komodo Edit LopeEdit Notepad++ XML Marker PSpad Commercial Editors UltraEdit EditPlus Not Recommended This page lists XML editors that have been mentioned on the JMRI users discussion group.įor more information on XML itself, please see our introductory page. The syntax as you work, give you useful hints, and provide more powerful editing tools. Still, using an editor that's "XML aware" can make things easier. Might have trouble with word processors that insist on reformatting the content). XML is a text format, and you can edit it with any convenient text editor (though you JMRI uses XML for a number of purposes: to hold decoder definitions, for its persistance system for configuration and panel information, and toĬreate parts of the website from other files.
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